Which came first, the blank slate or the writer?

Mardi Gras comes and goes here in New Orleans and I miss out on all the controversy. I think I have discovered the real reason some people get so queasy when talk of genetic engineering of intelligence arises.

If the comments on this forum are in any way indicative of how the dialog will go on the larger scale(and I suspect that they are) the discussion will be like every other debate about genetic engineering, cloning, or pre-emptive medical intervention.

The anti side will be ignorant of the basic science and will be composed of liberal art majors chattering about how wrong it is to “tamper with nature” and religious right-wingers chattering about how wrong it is to “tamper with god’s creation.” The pro side will be composed of those who understand the basic science involved and realize that this really is nothing new and nature has been doing it all along, but this side will be totally unable to communicate with the anti side because:

1)the anti side is ignorant of the basic science.

2)the anti side doesn’t really want a reasoned debate anyways, they just want to yell and scream about how wrong it is.

[ EDIT 10-2007] It took me a long time to realize that not everyone agrees that rationality should be the basis for all policy decisions. If you want to get across to those people, you have to speak to their heart, not their head.

Google Ads are SO much better than Doubleclick!

Nobody will probably notice this but me, so I’ll point it out because it’s so cool. My top-of-the-page ads(which you can remove by clicking here) no longer come from ad.doubleclick.net, which I have blocked at the level of the HOSTS file, but from pagead.googlesyndication.com. This is the cool part: no longer are they for bonzi buddy and the x10 spycam. They have apparently used the same algorithm to target ads to my page as they do for their search pages. Now my ads are for DNA sequencing and genotyping! I think that’s awesome.

HIV Vaccine affects hispanics and african americans differently from others.

There is a nice analysis of the HIV vaccine results at Lagniappe. This story has been all over the news, even making the local television news. Apparently, it’s supposed to be some big deal that the vaccince caused a greater immune response in hispanic and african americans than in asians or “others”. Who can practice medicine, now in the post genomic era, and not take as old news the fact that different genes may mean different medical treatment? I would certainly hope my doctor places patient care over being politically correct, wouldn’t you?

I am so ready for this to become a non-issue, but, as Derek mentions, it is going to come up more and more often now, like a repressed memory whose only release is through catharsis. Only then we can start talking about what we’re going to do about it.

Genetic influences on intelligence and cross-cultural concepts of beauty.

Razib has invited me to take my seat at his roundtable, and I am honored to do so. Upon logging in to write my first post, I noticed that 4 out of the 5 most recent pings were from “Gene Expression contributors are racists” discussions. Of course, that’s just par for the course when you’re discussing such emotionally charged issues as genetic(i.e. racial) influences on intelligence and cross-cultural concepts of beauty.

[EDIT 2-12-2007 – I regret that I kinda flaked out after this, but I’m glad to see that Gene Expression is still around.

Are Scientific Journals Self-censoring?

Lagniappe is sounding off on the decision of the major scientific journals to self-censor material which could be used by terrorists. All kinds of things are being done now, that we normally wouldn’t do, due to fears about terrorism. There are reasons why we don’t normally do these things. We don’t normally keep a database of information about where foreign nationals are going, what they’re doing, and what they’re buying. Our government doesn’t normally provide us a number to call in case our neighbors look like they’re doing something suspicious. We don’t normally do anything to infringe on the freedom of the press. It’s the same issue underlying all three issues: respect of individual liberty. In the extreme case we need to take one of these measures, it should be understood that serious oversight and openness must be part of the process.

The way the journals are handling the issue is a great example of the way to handle an issue like this. For the tiny number of cases that require it, they work with the author to get them to focus their article on the things necessary to make their point, but not to give anyone any unrelated ideas. If additional information is desired by someone, well…any responsible researcher knows how to handle requests for additional information. They are familiar with the people in their field, so they can handle requests for information such as, “Exactly which conditions most greatly contributed to pathogenicity” in somewhat similiar fashion to the way you would handle a request to borrow your axe. You might loan it to your neighbor willingly, but if somebody you don’t know shows up wearing a hockey mask and asks to borrow it, you’re gonna be a little more careful.
Thanks for the blogroll, Derek!

Peter Schultz makes mRNA cry.

I recently heard a presentation on this crazy guy, Peter Schultz, who has engineered bacteria to use para-aminophenylalanine instead of amber codons. The bacteria synthesize para-phenylalanine, have a para-phenylalanine tRNA synthetase, and and insert it with very high fidelity whenever the amber codon is found. The amber codon, which causes the ribosome to stop reading the mRNA when it’s found, is apparently quite rare, and because bacterial mRNAs aren’t as processed as eukaryotic ones, the bacteria get along quite well. I was thinking it would be really keen to make a series of mutants, each of which incorporated a different D-amino acid instead of the L version. Then, analysis of the structures of the D tRNA synthetases, of the ribosome translating the codon, and of the resulting protein could contribute a little information towards answering why we use all L amino acids.

Coincidentally, while I was googling a good link for this story, I found Lagniappe, who just blogged this story about the same time I heard the presentation.

Here’s Schultz’s PDF in JACS.

Derek, if you’re reading this, you’re the number one link at google for para-aminophenylalanine. Kinda funny that I find a blogspot blog as the number one search result for something right after google buys pyra. However, there were only 2 results total, so I only mention this to be funny, not to suggest anything conspiratorial.